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KMID : 0370219970410050666
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Yakhak Hoeji
1997 Volume.41 No. 5 p.666 ~ p.671
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Effects of Tyrosine Phosphorylation Inhibitors on Vascular Smooth Muscle Contraction
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정진영/Jung JY
윤여표/안희열/Yun YP/Ahn HY
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Abstract
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We studied effects of genistein and tyrphostin, inhibitors of tyrosine kinase, on contractions induced by high K+ and norepinephrine in rat aorta. Genistein (10- 6~10-4M) and tyrphostin (10-5~10-4M) inhibited high K+ and norepinephrine-induced sustained contractions, respectively in a concentration-dependent manner. High K+ and norepinephrine caused an increase in 45Ca2+ uptake while 10-4M genistein and tyrphostin inhibited the K+ and norepinephrine-increased 45Ca2+ uptake, respectively. These results show that inhibitor of tyrosine kinase blocks the voltage-and receptor-operated Ca2+ channels in rat aorta, respectively.
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